Wish I could help more, but not really familiar at all with the engine and it's workings regarding Bloodlines, Zer0, Malkav, or Philosopher can probably give you more help. However, that seems to be a LOT of system resources being used during your session, you might be running out of ram. Try using this utility and see if it helps any at all http://iobit.com/gamebooster.html
While it probably is not going to solve your crash, it may help in giving you smoother game play with a few more frames per sec and free up some resources, which might result in LESS crashes. I've used this utility for quite awhile now with no ill effects, and it won't install anything unknown / unwanted on your PC.
Hope that helps some!